Product: Anti-Desmoglein 2, clone 6D8
Cat. No.: MC-213 (1 mL)
Description:
Desmoglein 2 is a member of the desmosomal
cadherin family that comprise the desmogleins
and desmocollins. Desmosomes are cell-cell
junctions in most epithelial cells and serve to link
the intermediate filament cytoskeletons of
adjacent cells. Within the desmosome the
extracellular desmocollins, whereas the
intracellular domain is essential for binding to
the desmosomal plaque protein, plakoglobin.
Desmoglein 2 is synthesized in the basal layers,
depending on the certain types of epidermis.
Specificity:
The antibody reacts with the 165 kDa
desmoglein 2 protein. Furthermore it does NOT
cross-react with desmoglein 1 or desmolglein 3.
Clone 6D8 does NOT inhibit the biological
activity of desmoglein 2.
Ig Isotype:
Mouse IgG1
Species Reactivity:
Human. NOT suitable for rat tissues. Others not
tested.
Format:
1 mL at 100 μg/mL of 0.2 μm filtered antibody
solution in PBS, containing 0.02% sodium azide
and 0.1% protein stabilizer.
Storage:
Store at 4°C for short term.
Applications and Suggested Dilutions:

Immunofluorescence: Use at a 1:10 dilution.

Immunoprecipitation

Western blotting: Use at a 1:10 dilution.
The optimal dilution for a specific application
should be determined by the researcher.
Limitations:
For in vitro research use only. Not for use in
diagnostics or in humans.
Warranty:
No warranties, expressed or implied, are made
regarding the use of this product. KAMIYA
BIOMEDICAL COMPANY is not liable for any
damage, personal injury, or economic loss
caused by this product.