人类疾病的发展十分复杂，以人本身作为实验对象来深入探讨疾病发生机制，推动医药学的发展来之缓慢。借助动物模型的间接研究，可避免在人体上进行实验所带来的风险和伦理问题，可以有意识地改变那些在自然条件下不可能或不易排除的因素，以便更准确地观察模型的实验结果并与人类疾病进行比较研究，有助于科研者更方便有效地认识人类疾病的发生发展规律，研究防治措施。
翌圣生物提供多种类型的造模产品，包括结肠炎、胰腺炎、糖尿病和高血压等，详细信息如下表。
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客户案例
01
——含硫量16-20%，游离硫<0.2%，模拟人UC模型，安全高效
客户1：
客户来源：南京农业大学
动物类型：C57BL/6小鼠
造模方法：3% (w/v) DSS自由饮用7天
引用自：doi.org/10.1016/j.jnutbio.2020.108438
客户2：
客户来源：暨南大学
动物类型：BALB/c小鼠
造模方法：
1. 10 mg/kg AOM处理小鼠后用纯水自由饮1周；
2. 2.5%（w/v）DSS自由饮用1周，换纯水自由饮用2周
3. 步骤2重复3次。
引用自：doi: 10.3389/fphar.2020.586885
02
——十肽分子形式，纯度（HPLC）≥97%
客户3：
客户来源：上海交通大学医学院
实验动物：Balb/c小鼠
造模方法：以1小时间隔腹腔注射7次50 μg/kg雨蛙素，并在最后一次同时注LPS (10 mg/kg)诱导SAP。
引用自：doi.org/10.1016/j. ebiom.2022.103959
03
客户4：
客户来源：华中科技大学同济医学院
引用自：DOI: 10.1021/acsami.1c24569
部分客户文献
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[2] Lingjun Tong, Haining Hao, Zhe Zhang,et al.Milk-derived extracellular vesicles alleviate ulcerative colitis by regulating the gut immunity and reshaping the gut microbiota[J].Theranostics.2021; 11(17): 8570-8586 IF=11.556
[3] Li, Y., Dong, J., Xiao, H., Zhang, S., Wang, B., Cui, M., & Fan, S. Gut commensal derived-valeric acid protects against radiation injuries. Gut Microbes,.2020 .1–18.IF=10.245
[4] Jingjing Gan, Yuxiao Liu, Lingyu Sun,et al.Orally administrated nucleotide-delivery particles from microfluidics for inflammatory bowel disease treatment[J].Applied Materials Today.2021 Dec;25:101231 IF=10.041
[5] JialiDong,YuanLi,HuiwenXiao,et al.Oral microbiota affects the efficacy and prognosis of radiotherapy for colorectal cancer in mouse models[J].Cell reports.2021, 109886.IF=9.423
[6] Xi Z, Ahmad E, Zhang W, et al. Dual-modified nanoparticles overcome sequential absorption barriers for oral insulin delivery. J Control Release. 2022;342:1-13. doi:10.1016/j.jconrel.2021.11.045.IF=9.776
[7] Xu Z, Liu Y, Ma R, et al. Thermosensitive Hydrogel Incorporating Prussian Blue Nanoparticles Promotes Diabetic Wound Healing via ROS Scavenging and Mitochondrial Function Restoration. ACS Appl Mater Interfaces. 2022;14(12):14059-14071. doi:10.1021/acsami.1c24569.IF=9.229
[8] He R, Shi J, Xu D, et al. SULF2 enhances GDF15-SMAD axis to facilitate the initiation and progression of pancreatic cancer. Cancer Lett. 2022;538:215693. doi:10.1016/j.canlet.2022.215693.IF=8.679
[9] Zhang L, Shi J, Du D, et al. Ketogenesis acts as an endogenous protective programme to restrain inflammatory macrophage activation during acute pancreatitis. EBioMedicine. 2022;78:103959. doi:10.1016/j.ebiom.2022.103959.IF=8.143
[10]Xuan Zhang, Xia Gao, Xiangzhou Yi, et al. Multi-targeting inulin-based nanoparticles with cannabidiol for effective prevention of ulcerative colitis[J]. Materials Today Bio.2024, 25100965. IF=8.2